Cardiac On-pump Surgery
Conditions
Brief summary
Organ protection, volatile anesthetics, postconditioning. Sedation of patients on ICU after cardiac surgery with cardiopulmonary bypass with either propofol or sevoflurane. Evaluation of organ function and inflammatory mediators in the blood.
Interventions
DRUGSevoflurane
Sedation with sevoflurane
DRUGPropofol
Sedation on intensive care unit with propofol
Sponsors
University of Zurich
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
18 Years to 90 Years
Healthy volunteers
No
Inclusion criteria
* CABG and/or heart valve surgery with CPB * Ejection fraction (EF) = 30% * Canadian Cardiovascular Society (CCS) classification = 3 * Ages 18 to 90 years old
Exclusion criteria
* Pulmonary disease: forced expiratory volume in one second (FEV1) \< 80%; FEV1/forced vital capacity (FVC) \< 70% * Renal disease and/ or creatinine-clearance \< 60 ml/min * Previous cardiac surgery * Emergency procedures * Postoperative intra aortic balloon pump (IABP) requirement * Myocardial infarction \< 7d * Steroid treatment * Insulin-dependent diabetes * Pregnancy
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Myocardial injury markers (myoglobin, creatine kinase, myocard specific creatine kinase, and troponin T) | Start and end of ICU stay |
Secondary
| Measure | Time frame |
|---|---|
| Oxygenation index, postoperative pulmonary complications, ICU stay (days), length of hospitalisation | Start with surgery until end of hospitalisation |
Countries
Switzerland
Outcome results
None listed