Depression
Conditions
Keywords
Depression, Symptom scales, Symptom measures, Vancouver Semi-Structured Interview for Depression, V-SID, VSID, treatment-as-usual, treatment as usual, open-label, open label, Major Depressive Episode, MDE
Brief summary
The primary goal of this study is to compare a new symptoms rating questionnaire, called the Vancouver Semi-Structured Interview for Depression (V-SID), to the traditionally used questionnaires. The investigators predict that the V-SID will be more sensitive to patients' improvement than are traditional questionnaires.
Detailed description
Depression is sometimes associated with difficulties in thinking skills. Recent evidence suggests that in those people who have thinking difficulties, effective treatment and improvement of depression can also result in improved thinking skills. Therefore, a test of thinking skills is included in this study. This study will also evaluate three other potential indicators of treatment response: cortisol, cytokines, and grip strength.
Interventions
OTHERTreatment-as-usual
Sponsors
AstraZeneca
Dr. D McIntosh & Dr. K Kjernisted Clinical Research Inc.
Study design
Observational model
CASE_ONLY
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
19 Years to 65 Years
Healthy volunteers
No
Inclusion criteria
* Major depressive episode, diagnosed using the Mini-International Neuropsychiatric Interview (MINI) * Depression not currently effectively treated * Age 19 to 65 years
Exclusion criteria
* Co-morbid Axis I disorders (co-morbid anxiety symptoms, including generalized anxiety or panic attacks, are not exclusionary if they are present in the context of a primary mood disorder)
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Quality of Life Enjoyment Satisfaction Questionnaire (Q-LES-Q) | Day 0, Week 8 |
| Hamilton Rating Scale for Depression (HAM-D) | Pre-Baseline, Day 0, Week 1, Week 4, Week 8 |
| Vancouver Semi-Structured Interview for Depression (V-SID) | Pre-Baseline, Day 0, Week 1, Week 4, Week 8 |
| Montgomery-Asberg Depression Rating Scale (MADRS) | Pre-Baseline, Day 0, Week 1, Week 4, Week 8 |
| Clinical Global Impression | Pre-Baseline, Day 0, Week 1, Week 4, Week 8, Followup |
| Hamilton Rating Scale for Anxiety (HAM-A) | Pre-Baseline, Day 0, Week 1, Week 4, Week 8 |
| British Columbia Major Depression Inventory (BC-MDI) | Pre-Baseline, Day 0, Week 1, Week 4, Week 8 |
Secondary
| Measure | Time frame |
|---|---|
| British Columbia Cognitive Complaints Inventory (BC-CCI) | Pre-Baseline, Day 0, Week 1, Week 4, Week 8 |
| Grip strength | Pre-Baseline, Day 0, Week 8 |
| Cortisol level | Day 0, Week 8 |
| Neuroimmunobiologic markers | Pre-Baseline, Week 8 |
| Evaluation for Metabolic Syndrome | Day 0, Week 8, Followup |
| CNS Vital Signs | Pre-Baseline, Day 0, Week 8 |
Countries
Canada
Outcome results
None listed