Endothelial Function, Platelet Aggregation
Conditions
Keywords
Secondhand smoke, passive smoking, platelet function, endothelial function
Brief summary
Passive smoking is associated with an increased risk for cardiovascular events. However, the exact mechanisms by which passive smoking affects cardiovascular health are not entirely understood. In the present study, the researchers investigate the effects of short-term exposure to secondhand smoke on platelet function and peripheral microvascular endothelial function in healthy individuals. For this purpose, platelet function and endothelial function are measured before and after a 1-hour exposure to secondhand smoke in a concentration that is encountered in bars and restaurants without smoke-free policies. The researchers' hypothesis is that short-term exposure leads to platelet activation and impairment of endothelial function.
Interventions
OTHERsecondhand smoke exposure
Participants will be exposed to secondhand smoke for one hour. As a measure of secondhand smoke exposition, room carbon monoxide concentration will be continuously measured using an Ambient Carbon Monoxide Monitor APMA-360 and kept constant between 4.5-6.0 ppm. Levels in this magnitude are typically seen in smoking areas of restaurants and bars.
Sponsors
Kantonsspital Graubünden
Study design
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
PREVENTION
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
18 Years to 50 Years
Healthy volunteers
Yes
Inclusion criteria
* healthy individuals * nonsmokers * no regular medication (in particular no drugs affecting platelet function or vascular function)
Exclusion criteria
* exposition to secondhand smoke within 1 week before inclusion * use of drugs affecting platelet function or vascular function within 1 week before study inclusion
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Change in platelet aggregation and/or endothelial function | 12-24 hours |
Countries
Switzerland
Outcome results
None listed