Cardiovascular Disease
Conditions
Keywords
The early origin of cardiovascular disease
Brief summary
Small body size at birth, slow weight gain during infancy and increase in body mass index after 2 years are independent risk factors for cardiovascular disease and the metabolic syndrome. There is a large gap in our understanding of how early growth affects the cardiovascular system. Possible mechanisms include alterations in body composition, in cardiac structure, in vascular function, in renal function and epigenetic processes. The Objective is to determine how size at birth and growth during infancy and childhood affect: body composition, cardiac structure and function, vascular and endothelial function, renal function, metabolic status and transcriptional and epigenetic characteristics.
Interventions
None listed
Sponsors
Danone Institute International
Study design
Observational model
COHORT
Time perspective
RETROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to 25 Years
Healthy volunteers
Yes
Inclusion criteria
* Male and female volunteers students aged between 18-25 years old * Having growth records
Exclusion criteria
* If young women subject without contraception,or pregnant
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| To determine how size at birth and growth during infancy and childhood affect: body composition, cardiac structure and function, vascular and endothelial function, renal function, metabolic status and transcriptional and epigenetic characteristics | 3 years |
Countries
France
Contacts
Primary ContactUmberto SIMEONI, MD,PhD
Backup ContactOlivier BLIN, MD,PhD
Outcome results
None listed