Acute Asthma
Conditions
Keywords
asthma, heliox, bronchodilators, posture
Brief summary
The purpose of this study is to verify that nebulization with bronchodilators associated with heliox gas (helium + oxygen) and the posture of a leaning forward truck is effective in patients with an asthma attack.
Detailed description
When associated with inhaled bronchodilators, the heliox, a mixture of helium and oxygen in obstructive lung diseases with asthma, reduces the turbulence of airflow despite high rates, due to its low density. Although the first report of the use of heliox in the treatment of asthma dating to 1935, few controlled studies are available clarify the impact of the use of heliox in hospital admission of patients with acute asthma attacks refractory to standard treatment. The severe airflow obstruction, observed in cases of acute asthma, also leads to lung hyperinflation that favors the increase of respiratory work by increasing the load for the inspiratory muscles by placing them at a mechanical disadvantage. Various body positions were studied relating them to muscle activity with mechanical disadvantage. These studies suggest that the influence posture acts mainly in the position of the diaphragm, thus, increasing the stress related to other muscles such as the abdominals and the effect of gravity on these. This study aims to: assess the efficiency of the positioning body associated with nebulization with bronchodilators carried by heliox during acute severe asthma in adults, using as the primary outcomes FEV1, FVC and PEF and secondary outcomes as the Borg scale, inspiratory capacity, RR, HR and SpO2.
Interventions
OTHERHELIOX
The nebulization was conducted in the same way that heliox + posture group, except the attitude of trunk, where the patients in this group did the Nebulizer with the trunk upright.
OTHEROXYGEN
The NEBULIZATION was performed the same way as the heliox group, except for torso posture, where the patients in this group with the trunk upright Nebulizer Oxygen for cars have A NEBULIZATION.
OTHERHELIOX+POSTURE
Patients underwent two carried by heliox nebulization associated with fenoterol (2.5 mg) and ipratropium bromide (0.25 mg). We used three ml of saline solution at 0.9%. For nebulization with heliox or oxygen, was used a system of distribution not invasive, semi-closed in a mask that is non toxic connected to a piece Y with a nebulizer in a follow and a bag of tank with a capacity for 2.5 L in the other connected with a valve action. This system was used so that there was a dilution gas. The proportion of 80:20 heliox was used (80% helium: 20% oxygen). To postural change in groups and heliox Oxygen + posture + posture, oriented to the participants to maintain an angle of inclination of the trunk and elbows supported on the thighs, measured from the anterior axillary line and lateral epicondyle of the femur, between 50th and 60th .
OTHEROXYGEN + POSTURE
The NEBULIZATION was conducted in the same way that heliox + posture GROUP, however the patients in this group have the Oxygen for Carr A NEBULIZATION
Sponsors
Universidade Federal de Pernambuco
Study design
Allocation
RANDOMIZED
Intervention model
FACTORIAL
Primary purpose
TREATMENT
Masking
DOUBLE (Subject, Investigator)
Eligibility
Sex/Gender
ALL
Age
18 Years to 65 Years
Healthy volunteers
No
Inclusion criteria
* reversibility of bronchial obstruction after administration of bronchodilator drugs for at least 10% in FEV1 * a clinical diagnosis of acute severe asthma * a history of asthma over 1 year * duration of the crisis of current asthma lasting less than seven days
Exclusion criteria
* were unable to understand or perform the spirometric maneuver * smoking (within the last 3 years associated with a higher consumption of 100 cigarettes/year) * other pulmonary comorbidities * lower to upper airways * heart failure * heart rate greater than 150 bpm * systolic pressure below 90 mmHg or greater than 150 MHG * pregnancy * inability to stay inline with the trunk forward
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Spirometry | 6 months |
Secondary
| Measure | Time frame |
|---|---|
| Respiratory rate | 6 months |
| Peripheral oxygen saturation | 6 months |
| Borg scale | 6 months |
| Heart rate | 6 months |
Countries
Brazil
Outcome results
None listed