Computed Tomography Coronary Angiography (CTCA) and Coronary Flow in Stenosis Analysis

CT Coronary Angiography: Coronary Flow Quantification Supplements Morphological Stenosis Analysis

Status

Completed

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT00921440

Enrollment

Registered

2009-06-16

Start date

2007-08-31

Completion date

2008-07-31

Last updated

2009-06-16

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Coronary Artery Disease

Keywords

coronary artery, stenosis

Brief summary

The investigators' rationale was to evaluate whether a 64-slice CT scanner allows accurate measurement of computed tomographic changes in coronary artery flow profiles and whether CT flow measurements are suitable for classifying the significance and hemodynamic relevance of a stenosis and thereby supplement as a functional parameter for morphological stenosis analysis.

Detailed description

A total of 50 patients prospectively underwent computed tomography coronary angiography (CTCA) in a multidetector CT scanner (Brilliance 64, Philips) ± 1 day before or after invasive coronary angiography (ICA). Immediately thereafter, 2 radiologists reviewed the imaging data to detect any vessel segments with morphology poorly evaluable by CTCA. A locally constant cyclical measurement was acquired in these coronary arteries in breath-hold technique during the passage of a 50ml bolus of contrast media. For analysis, time-density curves of the bolus passage were registered in the coronary artery and the aorta (internal reference), the up-slopes were determined and correlated with each other. The results were compared with the ICA findings.

Interventions

None listed

Study design

Observational model

COHORT

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

51 Years to No maximum

Healthy volunteers

Inclusion criteria

* Clinically known or presumed CAD * Age \> 50 years * Hospitalization for invasive coronary angiography * Sinus rhythm * Written informed consent by the patient to participate in the study after comprehensive presentation of the facts

Exclusion criteria

* Age \<= 50 years * Contraindications to contrast media administration (medical history of iodine allergy, nephropathy, latent or manifest hyperthyroidism) * Arrhythmias * Dyspnea at rest, acute unstable angina pectoris, acute myocardial infarction * Pregnancy * Implanted pacemaker * Unwillingness of patient to consent to the study

Outcome results