Anesthesia
Conditions
Brief summary
The main objective if to evaluate the sparing effect of dexmedetomidine on the doses of propofol and remifentanil.
Interventions
DRUGNaCl 9/00
Same volume as in the dexmedetomidine group
DRUGdexmedetomidine
1 mcg/kg administered in 10 minutes followed by a continuous infusion of 0,5 mcg/kg/hr
Sponsors
Hopital Foch
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
TRIPLE (Subject, Caregiver, Investigator)
Eligibility
Sex/Gender
MALE
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* male patients scheduled for a general anesthesia
Exclusion criteria
* age lower than 18 years * allergy to propofol, or to soja or to peanuts, or to sufentanil, to remifentanil, or to morphine,or to a myorelaxant or to an excipient, * hypersensibility to sufentanil, or to remifentanil, or to other derivate of fentanyl, * history of central nervous system disease, * patients receiving a psychotropic treatment or an agonist-antagonist opiate, * hypovolemic patients, * patients receiving a cardio-vascular treatment, * expected bleeding surgical procedure, * simultaneous general and loco-regional anesthesia, * severe hepatic insufficiency.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| administered doses of propofol and of remifentanil during anesthesia | end of anesthesia |
Secondary
| Measure | Time frame |
|---|---|
| delay before recovery | at the end of anesthesia |
| hemodynamic abnormalities requiring a treatment | end of anesthesia |
| postoperative morphine requirement | Third post-anesthetic hour |
| explicit memorisation | Second postoperative day |
Countries
France
Outcome results
None listed