Neonatal Infections, Streptococcus Agalactiae
Conditions
Keywords
Screening, real time PCR, Streptococcus agalactiae, Pregnant women
Brief summary
Group B streptococcus infections may be serious for the neonates. The infection can occur during the birth, by contact with the genital area. That is why the detection of this bacteria is systematically realised in pregnant women between 34 and 37 weeks of amenorrhea in order to give prophylactic antibiotic treatment in case or positive carriage. This strategy presents 2 disadvantages : (1) detection of the group B streptococcus at 34 and 37 weeks of amenorrhea in not predictive of a carriage at delivery, (2) many pregnant women escape from systematic screening, leading to a systematic antibiotic treatment, which means useless costs, and useless antibiotic exposure with resistant bacteria selection. Real time polymerase chain reaction (PCR) allows a rapid detection anytime with no specific microbiological qualification. The aim of the study is to assess the economic outcomes of this strategy and the epidemiological values for St Etienne hospital.
Interventions
None listed
Sponsors
Centre Hospitalier Universitaire de Saint Etienne
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
FEMALE
Age
18 Years to No maximum
Healthy volunteers
Yes
Inclusion criteria
* women giving birth
Exclusion criteria
* planned caesarian * minor * cervical diameter \> 5 cm * women giving birth at less than 35 weeks of amenorrhea * recent antibiotherapy
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| number of women receiving a useless antibiotic prevention | 1 day |
Secondary
| Measure | Time frame |
|---|---|
| economic outcomes | 1 day |
| epidemiological outcomes for group B streptococcus | 1 day |
| diagnosis efficacy of the real time PCR | 1 day |
Countries
France
Outcome results
None listed