Pneumonia
Conditions
Keywords
Hospital-Acquired Pneumonia, Gram Negative Bacteria
Brief summary
Nebulized Colistin for Adjunctive Therapy of Hospital-Acquired Pneumonia caused by Gram Negative Bacteria should be more effective than conventional therapy
Detailed description
Randomized Controlled Clinical Trial in hospitalized adult patients with hospital-acquired pneumonia. The patients are allocated to conventional group or nebulized colistin group. The conventional group receives conventional antibiotics whereas the nebulized colistin group receives nebulized colistin in addition to conventional antibiotics. The outcomes are clinical response and microbiological responses.
Interventions
DRUGnebulized colistin
nebulized colistin 75 mg every 12 hours
DRUGantibiotics
conventional parenteral antibiotics
Sponsors
Mahidol University
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* Adult (age\>18 years) hospitalized patient with hospital-acquired pneumonia due to Gram negative bacteria
Exclusion criteria
* pregnancy * lactating woman * colistin allergy * severe renal impairment * epilepsy
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Clinical response | 14 days after Treatment |
Secondary
| Measure | Time frame |
|---|---|
| Microbiological response and safety | 14 days after treatment |
Countries
Thailand
Outcome results
None listed