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Collecting and Storing Blood and Brain Tumor Tissue Samples From Children With Brain Tumors

A Children's Oncology Group Protocol for Collecting and Banking Pediatric Brain Tumor Research Specimens

Status
Completed
Phases
Unknown
Study type
Observational
Source
ClinicalTrials.gov
Registry ID
NCT00919750
Enrollment
1258
Registered
2009-06-12
Start date
2004-02-16
Completion date
2018-06-30
Last updated
2018-07-16

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Childhood Atypical Teratoid/Rhabdoid Tumor, Childhood Central Nervous System Germ Cell Tumor, Childhood Cerebral Anaplastic Astrocytoma, Childhood Cerebral Astrocytoma, Childhood Choroid Plexus Neoplasm, Childhood Craniopharyngioma, Childhood Grade III Meningioma, Childhood Grade II Meningioma, Childhood Grade I Meningioma, Childhood Infratentorial Ependymoma, Childhood Oligodendroglioma, Childhood Supratentorial Ependymoma, Ependymoma, Newly Diagnosed Childhood Ependymoma, Recurrent Childhood Cerebellar Astrocytoma, Recurrent Childhood Cerebral Astrocytoma, Recurrent Childhood Ependymoma, Recurrent Childhood Medulloblastoma, Recurrent Childhood Supratentorial Embryonal Tumor, Not Otherwise Specified, Recurrent Childhood Visual Pathway Glioma

Brief summary

The purpose of this study is to collect and store brain tissue samples and blood from children with brain cancer that will be tested in the laboratory. Collecting and storing samples of tumor tissue and blood from patients to test in the laboratory may help the study of cancer in the future.

Detailed description

OBJECTIVES: I. Collect brain tumor tissue and an accompanying blood sample from pediatric patients with brain tumors treated at Children?s Oncology Group institutions. II. Provide a repository for long-term storage of specimens from these patients. III. Make these specimens available to qualified researchers to understand the biology of pediatric brain tumors. OUTLINE: This is a multicenter study. Brain tumor tissue and blood specimens are collected from patients and banked for future study.

Interventions

OTHERCytology Specimen Collection Procedure

Correlative studies

Sponsors

National Cancer Institute (NCI)
CollaboratorNIH
Children's Oncology Group
Lead SponsorNETWORK

Eligibility

Sex/Gender
ALL
Age
No minimum to 18 Years
Healthy volunteers
No

Inclusion criteria

* Diagnosis of brain tumor * Previously treated at a Children?s Oncology Group (COG) institution * Patients are eligible at time of diagnosis, second-look surgery, recurrence, or development of a second malignant neoplasm * Must have brain tumor biological specimens derived from primary tumors of the CNS available for submission

Design outcomes

Primary

MeasureTime frame
Collection of brain tumor tissue and an accompanying blood sample from pediatric patients with brain tumors treated at Children?s Oncology Group institutionsUp to 16 years
Creation of a repository for long-term storage of these specimensUp to 16 years
Making these specimens available to qualified researchers to understand the biology of pediatric brain tumorsUp to 16 years

Countries

Australia, Canada, New Zealand, Puerto Rico, Switzerland, United States

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026