Natural History of Atherosclerosis

Natural 1-year History of Atherosclerosis in Asymptomatic Patients With Mild to Moderate Carotid Stenosis

Status

Completed

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT00918541

Enrollment

Registered

2009-06-11

Start date

2007-01-31

Completion date

2010-03-31

Last updated

2011-12-23

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Atherosclerosis

Keywords

atherosclerotic disease, progression, natural progression of atherosclerotic disease, natural history of atherosclerosis at the level of the carotid artery as evaluated by MRI

Brief summary

20 patients will be recruited. The aim of the study is to determine the natural progression of atherosclerotic disease.

Interventions

None listed

Study design

Observational model

COHORT

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

ALL

Healthy volunteers

Inclusion criteria

* stable carotid artery disease not requiring revascularization * asymptomatic carotid artery stenosis \< 80% or symptomatic patients with stenosis \< 60 % * prophylactic therapy with aspirin (\> 100mg/day, statin, blood pressure therapy if indicated (goal \< 130/80 mmHg)) * informed consent

Exclusion criteria

* non atherosclerotic occlusive disease (Bürgers disease) * uncontrolled BP (DBP \> 110 mmHg and/or SBP \> 200 mmHg) * hemorrhagic disease or platelet count \< 100'000 mm\^3 * Known active liver disease (elevations of GPT GOT or increased ammonia) * impaired renal function (crea \> 180 mmol/l) * pregnancy * severe claustrophobic reactions * short - term life - threatening pathology * physically unable to participate in the study * compliance not guaranteed

Design outcomes

Primary

Measure	Time frame
Progression of atherosclerotic plaque	12 months

Countries

Switzerland

Outcome results