Hyperlipidemia, Inflammation
Conditions
Keywords
Milk, Postprandial hyperlipidemia, Postprandial inflammation, Overweight
Brief summary
The purpose of this study is to determine whether the addition of milk or the milk constituents calcium and protein to a high-fat breakfast affects the postprandial lipid and inflammatory response.
Interventions
DIETARY_SUPPLEMENTMilk
500 mL low-fat milk added to high-fat meal
DIETARY_SUPPLEMENTProtein
Milk protein in 500 mL water added to high-fat meal
DIETARY_SUPPLEMENTCalcium
Milk calcium in 500 mL water added to high-fat meal
DIETARY_SUPPLEMENTControl
Lactose in 500 mL water added to high-fat meal
Sponsors
Nederlandse Zuivel Organisatie
Maastricht University Medical Center
Study design
Allocation
RANDOMIZED
Intervention model
CROSSOVER
Primary purpose
PREVENTION
Masking
NONE
Eligibility
Sex/Gender
MALE
Age
18 Years to 70 Years
Healthy volunteers
Yes
Inclusion criteria
* Body mass index (BMI) above 27 kg/m2
Exclusion criteria
* Smoking * Diabetes mellitus * Cardiovascular diseases * Familial hypercholesterolemia or lipid lowering medication * Severe conditions that might interfere with the study outcomes, such as COPD, asthma, rheumatoid arthritis, etc. * Unstable body weight * Abuse of alcohol or drugs * Participation in another biomedical study during the past 30 days * Having donated blood during the past 30 days
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Plasma inflammatory markers | 6 h after meal |
Secondary
| Measure | Time frame |
|---|---|
| Serum lipids | 6 h after meal |
Countries
Netherlands
Outcome results
None listed