Endothelial Dysfunction in Subjects With History of Premature Coronary Artery Disease

Randomized Placebo-controlled Crossover Trial of Endothelial Function Improvement in Subjects With History of Premature Coronary Artery Disease

Status

UNKNOWN

Phases

Phase 4

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT00917527

Enrollment

Registered

2009-06-10

Start date

2009-06-30

Completion date

2013-06-30

Last updated

2012-07-23

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Coronary Heart Disease

Keywords

Subjects with family history of coronary heart disease

Brief summary

The aim of this prospective study is to investigate the prevalence of endothelial dysfunction in subjects with family history of premature coronary heart disease. At the same time, the effect of atorvastatin in treating subclinical endothelial dysfunction in those patients will be evaluated.

Interventions

DRUGAtorvastatin

Atorvastatin 40mg/D for 6 weeks to improve endothelial dysfunction

Study design

Allocation

RANDOMIZED

Intervention model

CROSSOVER

Primary purpose

PREVENTION

Masking

QUADRUPLE (Subject, Caregiver, Investigator, Outcomes Assessor)

Eligibility

Sex/Gender

ALL

Age

18 Years to No maximum

Healthy volunteers

Inclusion criteria

* within 1 year * the siblings of premature coronary heart disease(male\<55years old, female\<65years old: Framingham Heart Study)patients admitted relevant hospital

Exclusion criteria

* Documented coronary heart disease * Any woman of childbearing potential who is pregnant, seeking to become pregnant or suspects that she may be pregnant.

Design outcomes

Primary

Measure	Time frame
improvement of endothelial dysfunction with endo-PAT2000	6 weeks later drug administration

Countries

South Korea

Contacts

Primary ContactHyuk-Jae Chang, MD, PhD

hjchang@yuhs.ac82-2-2228-8461

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026