Pulmonary Mass, Pulmonary Nodule
Conditions
Keywords
Lung cancer, Lung nodule, Transbronchial needle aspiration, Transbronchial lung biopsy, Bronchoscopy
Brief summary
The main purposes of this study are to assess the performance characteristics of transbronchial needle aspiration (TBNA) in the diagnosis of peripheral pulmonary lesions, and to identify the predictor variables of a positive aspirate.
Detailed description
In a recent systematic literature review (Rivera PM, Mehta AC; Chest 2007; 132: 1318-1488) TBNA showed the highest sensitivity in the diagnostic bronchoscopic approach to peripheral pulmonary lesions, as compared to the other available sampling techniques (transbronchial biopsy, brushing, washings). However, the Authors conclude that the data regarding TBNA in this setting deserve cautious interpretation because of the limited number of studies and the large differences in sample size). We designed the present study to assess the performance characteristics of TBNA, alone and in comparison with those of transbronchial biopsy, in the diagnosis of peripheral pulmonary lesions.
Interventions
PROCEDURETBNA + transbronchial lung biopsy + bronchial washing
Sponsors
Maggiore Bellaria Hospital, Bologna
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to 76 Years
Healthy volunteers
No
Inclusion criteria
* Age 18 years and older * Pulmonary nodule (\< 3 cm) or mass (\> 3 cm) at computed tomography
Exclusion criteria
* Refusal to sign informed consent * Uncontrolled coagulopathy * Pregnancy
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Assess sensitivity, specificity and accuracy of TBNA in the diagnosis of peripheral pulmonary lesions | 1 year |
Secondary
| Measure | Time frame |
|---|---|
| Evaluate the predictor variables associated with a positive TBNA result | 1 year |
| Compare the performance characteristics of TBNA and transbronchial lung biopsy | 1 year |
Countries
Italy
Outcome results
None listed