Arrhythmia, Cardiomyopathies, Congestive Heart Failure, Sudden Cardiac Death
Conditions
Keywords
Arrhythmia, Cardiac Arrest, Cardiomyopathy, Heart Failure
Brief summary
The purpose of this study is to determine whether waveforms of the intracardiac electrograms, acquired through an ICD, can be used: * to predict malignant ventricular arrhythmias, requiring appropriate ICD therapies, and * to predict progression of heart failure in patients with ICD.
Interventions
None listed
Sponsors
Washington University School of Medicine
Johns Hopkins University
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* history of acute MI at least 4 weeks old * non-ischemic LV dysfunction for at least 9 months * who have an EF \< or = to 35% * who was resuscitated from sudden cardiac arrest (ventricular tachyarrhythmia) * undergone implantation of an FDA-approved ICD for primary or secondary prevention of SCD
Exclusion criteria
* inability or unwillingness to provide valid informed consent * pregnancy * any condition other than cardiac disease that was associated with a high likelihood of death during 1 year after enrollment
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| sustained ventricular tachycardia with appropriate ICD therapies (either shock or ATP) | from enrollment up to 72 months |
Secondary
| Measure | Time frame |
|---|---|
| Composite heart failure outcome (HF hospitalization, HF death, heart transplant) | from enrollment up to 72 months |
| All-cause mortality | from enrollment up to 72 months |
Countries
United States
Outcome results
None listed