COPD & OSA
Conditions
Keywords
chronic obstructive airway disease, obstructive sleep apnea, continuous positive airway pressure
Brief summary
1. The first objective of this study is to determine the differences between, while the airway obstruction severity is the same, and the acute continuous positive airway pressure (CPAP) effect on chronic obstructive pulmonary disease (COPD) patients with overlap syndrome compared with COPD patients without in terms of sleep quality, autonomic nerve activity, biologic markers of systemic inflammatory, and exercise performance. 2. The second objective of this study is to evaluate the subacute (3 months treatment) CPAP effect on COPD patients with overlap syndrome in terms of pulmonary hemodynamic and right heart function, We will also determine the subacute effect of CPAP on sleep and life quality, autonomic nerve activity, biologic markers of systemic inflammatory, as well as exercise performance. 3. The last objective of this study is to evaluate the long term (12 months treatment) CPAP effect on COPD patients with overlap syndrome. The un-scheduled clinic or emergency department visiting, hospitalization, or mortality will be recorded to see if there is significant treatment effect in terms of reducing morbidity and mortality. The long term CPAP effect on sleep and life quality, autonomic nerve activity, biologic markers of systemic inflammatory, exercise performance, as well as pulmonary hemodynamic and right heart function will be re-evaluation.
Detailed description
COPD patients will be disturbed by season 12 months follow up is better than 18 months
Interventions
DEVICEcontinuous positive airway pressure
CPAP with adequate pressure for 1 day, 3 & 12 months
Sponsors
Chang Gung Memorial Hospital
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* chronic stable COPD * FEV1/FVC \< 70% * No response to beta-agonist * without acute exacerbation within2 months
Exclusion criteria
* Chronic respiratory failure (PaO2\<60 mmHg, PaCO2\>50 mmHg) * Clinical evidence of congestive heart failure * Facial defect and all the other condition that can't tolerate nasal mask * Malignancy
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| exercise performance | 3 days, 3 & 12 months | the condition of COPD patient will be disturbed by season factor 12 months follow up will be better than 18 months |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| autonomic nerve activity | 3 days, 3 & 12 months | the same reason as above |
| mortality and acute exacerbation | 1, 5, 10 years | — |
Countries
Taiwan
Outcome results
None listed