Endothelial Dysfunction, Metabolic Syndrome
Conditions
Keywords
endothelial, metabolic syndrome, hesperidin
Brief summary
It has been suggested that cardiovascular risk factors either independently or in cluster (metabolic syndrome) increase the risk of both type 2 diabetes (DM2) and cardiovascular diseases (CVD). Consumption of citrus fruits is linked to reduced cardiovascular morbidity and mortality. Hesperidin is a flavanone abundant in citrus fruit with putative vasodilator actions in vitro. While molecular mechanisms of vascular actions of hesperidin begin to be explored, no data on in vivo vascular effect of this flavanone has been ever acquired.
Interventions
DRUGHesperidin
Administration of oral Hesperidin, 500 mg/daily
DRUGPlacebo
Administration of oral Placebo, 500 mg/daily
Sponsors
University of Rome Tor Vergata
Study design
Allocation
RANDOMIZED
Intervention model
CROSSOVER
Primary purpose
TREATMENT
Masking
SINGLE (Subject)
Eligibility
Sex/Gender
ALL
Age
20 Years to 55 Years
Healthy volunteers
No
Inclusion criteria
* Metabolic Syndrome (ATPIII criteria) * BMI \<35 * Age 20-55
Exclusion criteria
* History of cancer. * History of cardiovascular diseases. * Any other acute or chronic illness which requires administration of steroids or other drugs able to interfere with glucose or lipid metabolism.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Safety of oral supplementation of hesperidin | 3 weeks |
Secondary
| Measure | Time frame |
|---|---|
| Endothelial function assessed by FMD %. Inflammatory status assessed by biochemical markers. | 3 weeks |
Countries
Italy
Outcome results
None listed