Validity and Cost-Effectiveness of a New Screening Test for Hepatocellular Carcinoma

Status

Completed

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT00912847

Enrollment

1018

Registered

2009-06-03

Start date

1997-10-31

Completion date

2004-04-30

Last updated

2009-06-03

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Hepatitis B Virus

Keywords

HBV carriers

Brief summary

The purpose of this study is: 1. To establish and compare the diagnostic utilities for hepatocellular carcinoma (HCC) screening tests of (a) HS-AFP, (b) AFP + US,(c) AFP alone and (d) US alone (within HBV carriers between age 40 and 70 years); 2. To establish the cost-effectiveness of the screening tests; 3. To compare tumor sizes, resection rates, and survival rates up to 18 months between those who were screened by HS-AFP those of a historical control group that was not screened.

Interventions

None listed

Study design

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

40 Years to 70 Years

Healthy volunteers

Inclusion criteria

* Age between 40 and 70 years * Seropositive for HBsAg * Child's A or B * Life expectancy of more than 2 years

Exclusion criteria

* Non-HBV related cirrhosis * History of malignancy

Outcome results