Bone and Body Composition, Obesity, Metabolic Syndrome, Physical Function, Quality of Life
Conditions
Brief summary
The broad aim is to determine efficacy of a weight loss diet higher in protein and lower in carbohydrate combined with low intensity exercise to favorably impact body composition, bone health, physical function, metabolic disease and quality of life compared to a conventional higher carbohydrate diet in overweight women over age 60.
Interventions
DIETARY_SUPPLEMENTWhey protein isolate
Loss of 10% baseline weight over 6 months, with whey protein isolate supplemented at 50g/day (two 25 g doses taken at breakfast and afternoon snack mixed with food or beverage)
DIETARY_SUPPLEMENTMaltodextrin powder supplement
Loss of 10% baseline weight over 6 months, with whey protein isolate supplemented at 50 g / day (two 25 g doses at breakfast and afternoon snack mixed with food or beverage)
Sponsors
University of Illinois at Urbana-Champaign
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
BASIC_SCIENCE
Masking
QUADRUPLE (Subject, Caregiver, Investigator, Outcomes Assessor)
Eligibility
Sex/Gender
FEMALE
Age
60 Years to 80 Years
Healthy volunteers
Yes
Inclusion criteria
* Body mass index \> 28 kg/m² * Clearance of primary physician to participate in diet and mild exercise
Exclusion criteria
* Medical condition contraindicating prescribed diet and exercise regimen * Type 2 Diabetes Mellitus * Physically active lifestyle (\>30 min moderate physical activity 2+ times weekly)
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Bone and body composition: Weight, percent fat, muscle and fat distribution in the thigh and abdomen and bone density and structural quality assessed by DXA and structural MRI | Baseline and post 6 months weight loss |
Secondary
| Measure | Time frame |
|---|---|
| Physical function: balance, gait, strength and activities of daily living | Baseline and post 6 months weight loss |
| Quality of life | Baseline and post 6 months weight loss |
| Metabolic syndrome: insulin resistance, blood pressure, blood lipids, waist circumference | Baseline and post 6 months weight loss |
| Acid-base balance | Baseline and post 1 and 6 months weight loss |
Countries
United States
Outcome results
None listed