Does APOE-e4 Predict Delirium and Cognitive Dysfunction After Surgery?

Does Apolipoprotein E Genotype Predict Delirium and Postoperative Cognitive Dysfunction?

Status

Completed

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT00911677

Enrollment

100

Registered

2009-06-02

Start date

2005-08-31

Completion date

2009-05-31

Last updated

2009-06-02

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Delirium, Postoperative Cognitive Dysfunction

Keywords

Delirium (MeSH Unique ID D003693), Cognition Disorders (MeSH Unique ID D003072), Postoperative Complications (MeSH Unique ID D011183), Apolipoproteins E (MeSH Unique ID D001057)

Brief summary

Patients with the APOE-ε4 genotype are at increased risk of both vascular dementia and peripheral vascular disease. Patients undergoing major vascular surgery are at particularly high risk of delirium and other, more subtle, changes in cognitive function following surgery. The hypothesis of this trial is that the APOE-ε4 genotype is associated with both delirium and postoperative cognitive dysfunction (POCD).

Interventions

None listed

Study design

Observational model

COHORT

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

60 Years to No maximum

Healthy volunteers

Inclusion criteria

* Age 60 or greater * Open repair of the abdominal aorta

Exclusion criteria

* refusal; * planned endovascular repair; * emergency surgery; * previous diagnosis of dementia, Parkinson's disease, or psychiatric illness; * active alcohol or substance abuse; and * physical inability to complete neuropsychometric testing.

Design outcomes

Primary

Measure	Time frame
Delirium as assessed by the Confusion Assessment Method	7 days postoperatively

Secondary

Measure	Time frame
POCD as assessed by a battery of 9 neuropsychometric tests	7 days postoperatively

Countries

Canada

Outcome results