Respiration, Artificial, Ventilator Weaning
Conditions
Keywords
weaning, mechanical ventilation
Brief summary
This study is a comparison of two most commonly used modes of weaning and the outcomes in the two groups.
Detailed description
Patients ventilated for more than 24 hours are randomized into two groups - one group of patients undergo gradual reduction of pressure support and in the other, T tube trials are used for weaning. The outcomes are compared in the two groups.
Interventions
PROCEDUREPressure support ventilation
These patients are weaned by gradual reduction of pressure support and extubated when they tolerate a pressure support of 7 cm of water for one hour.
PROCEDURESpontaneous breathing trials
These patients are weaned by giving a T piece trial with 8 cm of water pressure support and extubated when they tolerate it for one hour.
Sponsors
Post Graduate Institute of Medical Education and Research, Chandigarh
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
HEALTH_SERVICES_RESEARCH
Masking
TRIPLE (Subject, Caregiver, Investigator)
Eligibility
Sex/Gender
ALL
Age
10 Years to 70 Years
Healthy volunteers
No
Inclusion criteria
* Mechanically ventilated patients for more than 24 hours * Satisfies weaning criteria * RSBI \< 80 * Ratio of PaO2/FiO2 \> 250 * Arterial partial pressure of oxygen more than 60 mm Hg and carbon dioxide less than 50 mm Hg
Exclusion criteria
* Systolic blood pressure of less than 100 * Arterial partial pressure of oxygen less than 60 mm Hg * Poor sensorium
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Rate of weaning failure | 48 hours from extubation |
Secondary
| Measure | Time frame |
|---|---|
| Reintubation rates | 48 hours |
| Mortality rates | Until the time of discharge from hospital |
| Occurence of ventilator associated pneumonia | Until the date of discharge from hospital |
| Role of various factors that may influence the weaning outcome and hence predict the probability of successful weaning in a patient | during ICU stay |
| The influence of weaning outcome on mortality and the other complications of mechanical ventilation | during hospital stay |
| Duration from start of weaning to extubation | In hospital stay |
Countries
India
Contacts
Primary ContactDr. Ritesh Agarwal, MD, DM
Outcome results
None listed