Hepatocellular Carcinoma
Conditions
Keywords
Prognosis, Markers, Expression analysis, Hepatocellular carcinoma
Brief summary
Hepatocellular carcinoma is an aggressive disease with limited therapeutic options. Therefore, new approaches to treat this type of cancer are needed with immunotherapy potentially being one of these. As a first step in the development of novel therapies, expression analysis of specific markers, including tumor antigens will be carried out, and the correlation of expression with disease variables and clinical outcome will be assessed. This will be done retrospectively using archived hepatocellular carcinoma tissue samples.
Interventions
Analysis using RNA extracted from tissue samples already archived; Analysis by Fluorescent in situ hybridization (FISH) using tissue samples already archived.
Sponsors
GlaxoSmithKline
Study design
Observational model
CASE_ONLY
Time perspective
RETROSPECTIVE
Eligibility
Sex/Gender
ALL
Healthy volunteers
No
Inclusion criteria
* The patient has pathologically proven hepatocellular carcinoma (any stage) * All the data required are available from patient's records
Exclusion criteria
N/A
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The proportion of hepatocellular carcinoma patients whose tumor tissue expresses specific tumor antigens. | At the time of analysis |
| The prognostic character of the expression of the tumor antigens | At the time of analysis |
| Expression of c-MET in the same hepatocellular carcinoma tumor samples | At the time of analysis |
Countries
Taiwan, Thailand
Outcome results
None listed