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Introduction and Influence of Total Mesorectal Excision (TME) in the Treatment of Rectal Cancer

Introduction of Total Mesorectal Excision (TME) in the Treatment of Rectal Cancer. Influence of This New Operation Technique on Local Recurrence and Long-Time Survival. Retrospective Study: 1993-2001

Status
Completed
Phases
Unknown
Study type
Observational
Source
ClinicalTrials.gov
Registry ID
NCT00910143
Enrollment
194
Registered
2009-05-29
Start date
1993-01-31
Completion date
2001-12-31
Last updated
2009-05-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Rectal Cancer

Keywords

Rectal cancer, Colorectal Surgery, Surgery, Local neoplasm recurrence, survival, Follow-up Study

Brief summary

Total mesorectal excision (TME) is a rather new operation technique in the treatment of rectal cancer. It is known to reduce the rate of local recurrences. However, the influence on long-term survival is unclear.

Detailed description

Background The TME technique for rectal cancer surgery was introduced in our department in summer 1995. TME is known to reduce the rate of local recurrences. However, its influence on long-term survival in unclear. All patients with rectal cancer from 1993 to 2001 are reviewed. The patients charts are reviewed and the following main characteristics are retrieved: age, gender, time of operation, operation technique, tumor stage, tumor localisation, tumor size, neoadjuvant or adjuvant treatment, complications, follow-up with respect to the appearance of local recurrences and distant metastases. Comparison of two groups of patients. Group 1: patients operated before summer 1995, that is before the introduction of TME. Group 2: patients operated after summer 1995, that is after the introduction of TME. Objective Study the influence of a new operation method (TME) on outcome (local recurrence, survival). Methods All patients with rectal cancer from 1993 to 2001 are reviewed. The patients charts are reviewed and the following main characteristics are retrieved: age, gender, time of operation, operation technique, tumor stage, tumor localisation, tumor size, neoadjuvant or adjuvant treatment, complications, follow-up with respect to the appearance of local recurrences and distant metastases. Comparison of two groups of patients. Group 1: patients operated before summer 1995, that is before the introduction of TME. Group 2: patients operated after summer 1995, that is after the introduction of TME.

Interventions

PROCEDUREconventional rectal surgery

type of rectal surgery before the introduction of TME

PROCEDUREtotal mesorectal excision

total mesorectal excision

Sponsors

Insel Gruppe AG, University Hospital Bern
Lead SponsorOTHER

Study design

Observational model
COHORT
Time perspective
RETROSPECTIVE

Eligibility

Sex/Gender
ALL
Age
16 Years to No maximum
Healthy volunteers
No

Inclusion criteria

* adenocarcinoma of the rectum * 16 years and older

Design outcomes

Primary

MeasureTime frame
Local recurrence, recurrence-free survival, overall survival6 months and 1, 2, 3, 4 and 5 years after the operation

Secondary

MeasureTime frame
Surgical complicationsfirst 30 days after the operation
quality of life
Percentage of patients undergoing transcatheter arterial embolisation

Countries

Switzerland

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026