Femoral Block With or Without Ropivacaine for Analgesia After Total Knee Replacement (TKR)

A Randomized Trial Comparing the Efficacy on Post-operative Analgesia of Intra-articular Ropivacaine Added to a Femoral Block After Total Knee Replacement

Status

Completed

Phases

Phase 1Phase 2

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT00910013

Acronym

TKR

Enrollment

Registered

2009-05-29

Start date

2006-04-30

Completion date

2008-03-31

Last updated

2011-02-28

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Total Knee Replacement

Keywords

TKR, Femoral block, Ropivacaïne, intra-articular ropivacaïne, post-operative analgesia

Brief summary

Total knee replacement is a painful procedure. Many solutions have been proposed to diminish the post-operative doses of narcotics, including nerve blocks. The purpose of the study is to compare if the adjunction of intra-articular ropivacaine to a femoral block is more effective on narcotics consumption than the block alone after TKR.

Interventions

DRUGRopivacaine

0.5% intra-articular ropivacaïne (20cc)

Study design

Allocation

RANDOMIZED

Intervention model

PARALLEL

Primary purpose

TREATMENT

Masking

QUADRUPLE (Subject, Caregiver, Investigator, Outcomes Assessor)

Eligibility

Sex/Gender

ALL

Age

18 Years to No maximum

Healthy volunteers

Inclusion criteria

* Primary total knee replacement * Age \> 18 years old * Accept the study

Exclusion criteria

* Revision surgery * Use of anticoagulants drugs * Neurologic disorder * Unable to sign consent form

Design outcomes

Primary

Measure	Time frame
Narcotic consumption per 24 hours after surgery (mg/kg)	48 hours

Secondary

Measure	Time frame
VAS score at 24 hours	48 hours

Countries

Canada

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026