Functional Magnetic Resonance Imaging (fMRI) of Anosognosia in Amnestic Mild Cognitive Impairment (MCI) and Alzheimer's Disease (AD)

FMRI of Anosognosia in Amnestic MCI and AD: Focus on Cortical Midline Structures

Status

Completed

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT00908999

Enrollment

Registered

2009-05-27

Start date

2008-04-30

Completion date

2011-09-30

Last updated

2011-09-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Alzheimer's Disease, Anosognosia, Mild Cognitive Impairment

Keywords

anosognosia fMRI amnestic MCI Alzheimer, anosognosia in AD and MCI

Brief summary

This is a three year fMRI study conducted at the University of Wisconsin (UW) Hospital and the William. S. Middleton VA Hospital. This study is guided by the hypothesis that reduced fMRI activity and connectivity cortical midline structures (i.e., medial frontal and ventral posterior cingulate cortex) are physiologic abnormalities that relate strongly to the compromised insight into cognitive deficits, or anosognosia, shown by a subset of individuals with amnestic MCI (aMCI) and AD. Further, the investigators hypothesize that these regional changes in fMRI activity are predictive of faster progression from aMCI to AD.

Interventions

None listed

Study design

Observational model

CASE_CONTROL

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

60 Years to 90 Years

Healthy volunteers

Yes

Inclusion criteria

* Amnestic MCI: 1. Observation of memory decline by informant. 2. Mini Mental Status Exam (MMSE) score between 24 and 30. 3. Objective memory impairment on neuropsychological tests. 4. Intact functional abilities, and 4) no diagnosis of dementia. * AD: 1. A diagnosis of probable AD according with the NINDS-ADRDA and DSM-IV diagnostic criteria. 2. MMSE score between 16 and 27. All AD patients will have capacity to provide informed consent as judged by the referring physician.

Exclusion criteria

* MRI incompatibility; history of neurologic disease (including prior loss of consciousness of more than 10 minutes); prior neurosurgery; or chronic medical diseases (such as poorly controlled diabetes, renal disease, or poorly controlled hypertension). * Excluded medications include neuroleptics, short or long acting nitrates, and Warfarin. * Other exclusions include: less than 10 yrs of education; Hachinski scale of 4 or more; first language other than English; poor visual or auditory acuity; pregnancy.

Countries

United States

Outcome results