Study of the Effect of Inhaled Anesthetics on Diastolic Heart Function Using a Doppler-derived Efficiency Index

Changes in Diastolic Dysfunction With the Onset of Volatile Anesthesia in Patients Undergoing Coronary Artery Bypass Grafting as Determined by a Load-independent Efficiency Index Derived From the Parameterized Doppler Analysis of Left Ventricular Filling

Status

Completed

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT00907439

Enrollment

Registered

2009-05-22

Start date

2008-11-30

Completion date

2010-10-31

Last updated

2010-11-05

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Coronary Artery Disease, Diastolic Dysfunction, General Anesthesia

Keywords

Diastole, physiopathology, coronary artery disease, volatile anesthetic, sevoflurane

Brief summary

The purpose of this study is to determine the effect of inhaled anesthetic drugs upon diastolic heart function (heart suction and filling performance) in patients who are undergoing coronary bypass surgery.

Detailed description

Diastolic heart dysfunction is a significant cause of cardiovascular morbidity and is the cause of symptomatic heart failure in approximately one half of patients who are admitted to hospitals with heart failure symptoms. However, diastolic heart function remains difficult to measure objectively without cardiac catheterization. Diastolic heart dysfunction is also common among patients undergoing coronary bypass grafting (CABG) surgery. Despite the ubiquitous use of inhaled volatile drugs to maintain anesthesia in these patients, their effects upon diastolic heart function remain unclear.

Interventions

None listed

Study design

Observational model

COHORT

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

18 Years to No maximum

Healthy volunteers

Inclusion criteria

* Non-emergent coronary bypass grafting surgery * Left ventricular ejection fraction of 40% or greater

Exclusion criteria

* Myocardial infarction within 4 weeks * Greater than mild cardiac valvular pathology * Body mass index greater than 35 * Cardiac dysrhythmias or pacemaker therapy * Left bundle branch block * Uncontrolled gastroesophageal reflux disease

Design outcomes

Primary

Measure	Time frame
Diastolic efficiency index (derived from the parameterized analysis of transmitral early filling Doppler using the paradigm of the ventricle as a damped harmonic oscillator)	Following induction of volatile anesthesia

Secondary

Measure	Time frame
Diastolic efficiency index (derived from the parameterized analysis of transmitral early filling Doppler using the paradigm of the ventricle as a damped harmonic oscillator)	Following the onset of controlled ventilation

Countries

United States

Outcome results