Acute Ischemic Stroke, Pneumonia
Conditions
Keywords
acute stroke, ischemic stroke, pneumonia, chest infection, brain lesion, lesion topology, dysphagia, sympathetic activation, immunosuppression
Brief summary
Pneumonia is a frequent complication of acute stroke and is associated with increased mortality and long-term impairment in the affected subjects. In previous studies, a number of clinical (e.g., dysphagia, severe neurological impairment, mechanical ventilation), radiological (e.g., large infarctions in the territory of middle cerebral artery, insular infarction) and biochemical (e.g., increased serum levels of C-reactive protein, decreased levels of CD4+ T-lymphocytes) findings have been reported as risk factors of stroke-related chest infection. The present study (PRECAST) aims to identify a small set out of these previously described risk factors that can predict stroke-related pneumonia with high sensitivity and specificity.
Interventions
None listed
Sponsors
University of Rostock
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* acute ischemic stroke * admission to the neurological intensive care unit or stroke unit within 24 hours after stroke onset * clearly assessed brain lesion location
Exclusion criteria
* previous large (non-lacunar) stroke * chest infection present already on hospital admission * mechanical ventilation already on day 1 or 2 after hospital admission * treatment with immunosuppressive drugs
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| diagnosis of chest infection within 7 days after stroke | days 1-7 after stroke |
Countries
Germany
Outcome results
None listed