Demonstration of the Dynamic Hypothesis of Latent Tuberculosis Infection

Status

UNKNOWN

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT00905970

Acronym

HYPDYN

Enrollment

105

Registered

2009-05-21

Start date

2009-05-31

Completion date

2011-12-31

Last updated

2011-07-11

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Latent Tuberculosis Infection

Brief summary

It is traditionally considered that the development of Latent Tuberculosis Infection (LTBI) is due to the M. tuberculosis ability to develop a dormancy state within well-structured lesions (granulomas), which can remain in the lung of the host even for life. A new original hypothesis has been developed in the Experimental Tuberculosis Unit based on scientific evidence that take into account the idea that a lesion cannot be held forever, because the host tends to remove any lesion in order to rebuild the original parenchyma, in a healing process. Even if M. tuberculosis can remain in a dormant/non-replicating state for a long period, this is an important but not sufficient factor to explain the LTBI. The Dynamic Hypothesis tries to explain the existence of LTBI in spite of the healing process that could remove it by a constant reinfection of the host's tissue. While the Static view defends the induction of active TB after the reactivation of the bacilli from and old lesion; while the Dynamic view wants to demonstrate that there is a constant induction of new granulomas. In case one of these new lesions takes place in the upper lobe privileged zone, the possibility to induce a cavity would appear, developing an active Tuberculosis (TB).

Interventions

None listed

Study design

Observational model

COHORT

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

18 Years to No maximum

Healthy volunteers

Inclusion criteria

* being at least 18 years old * to be M.tuberculosis infected (diagnosed by a positive TST with or without a positive result in the QuantiFeron-TB-Gold In tube assay)

Exclusion criteria

* active TB * individuals not willing to participate in the study and or not willing to sign the informed consent form * individuals not able to decide their participation in the study

Design outcomes

Primary

Measure	Time frame
QuantiFeron-Gold-In Tube method assay	Every 6 months during 3 years
Detection of M.tuberculosis DNA and RNA in the exhaled breath condensate	Once every year (every 6 months if possible), during 3 years

Countries

Spain

Contacts

Primary ContactCristina Vilaplana, MD

cvilaplana@gmail.com+3493497861

Backup ContactPere-Joan Cardona, MD, PhD

pjcardona.igtp.germanstrias@gencat.cat+34934978686

Outcome results