Left Ventricular Failure
Conditions
Keywords
Left ventricular failure, chronic heart failure, Pacemaker, Resynchronisation therapy, Exercise, Endurance exercise
Brief summary
The investigators will evaluate the effects of an exercise program (walking on a treadmill) on the physical performance, the cardiorespiratory function, the proclivity to heart arrhythmias and the quality of life of patients with severely impaired left ventricular function and a bi-ventricular resynchronization pacemaker.
Interventions
OTHEREndurance exercise
The patients carry out an exercise program (walking on a treadmill) three times weekly for 12 weeks at a speed corresponding with an intensity of 70% of VO2max.
Sponsors
Charite University, Berlin, Germany
Study design
Allocation
RANDOMIZED
Intervention model
CROSSOVER
Primary purpose
TREATMENT
Masking
SINGLE (Investigator)
Eligibility
Sex/Gender
ALL
Age
18 Years to 75 Years
Healthy volunteers
No
Inclusion criteria
* Left ventricular failure * Resynchronization therapy with a biventricular pacemaker * Ability to understand written German
Exclusion criteria
* Age over 75 years * Severe cardiac arrhythmia * All conditions which can be aggravated by an exercise program
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Maximal oxygen uptake (VO2max) | At recruitment and after 12 weeks |
Secondary
| Measure | Time frame |
|---|---|
| Body mass index (BMI) | At recruitment and after 12 weeks |
| Brain natriuretic peptide (BNP) | At recruitment and after 12 weeks |
| Body composition | At recruitment and after 12 weeks |
| Mood | At recruitment and after 12 weeks |
Countries
Germany
Contacts
Primary ContactFernando Dimeo, MD
Outcome results
None listed