Metabolic Fate Modifications of Saturated Fats After an Overfeeding

Status

Completed

Phases

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT00905892

Acronym

SURNUT

Enrollment

Registered

2009-05-21

Start date

2005-09-30

Completion date

2010-03-31

Last updated

2011-06-23

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Inflammation, Lipid Metabolism, Obesity

Keywords

overfeeding, stable isotopes, lipoprotein metabolism, lipid oxidation, fat distribution, gene expression, endotoxemia, mass spectrometry/gas chromatography

Brief summary

The purpose of this study is to determine the partitioning of exogenous lipids in the postprandial period while a study of overfeeding. The method is based on the incorporation of a stable isotopic tracer (d31\_palmitic acid, d31\_C16) in lipoprotein triglycerides (TG-CHYLOMICRON and TG-VLDL) and in free fatty acids (FFA).

Detailed description

Healthy overweight and lean young men are subjected to an overfeeding during 56 days which corresponds to a supplement of 761 Kcal/day. During two exploration days (before : D0 et after : D56 overfeeding) they have ingested a breakfast with tracer (d31\_palmitic acid, d31\_C16, 20mg/kg) and blood and urine samples were collected every hour of each exploration day. The enrichment in deuterium was measured by gas chromatography-organic mass spectrometry (GC-OMS) in palmitic acid pool of lipid fractions.

Interventions

DIETARY_SUPPLEMENTHyperlipidic overfeeding

100g per day of cheese + 40g per day of almonds + 20g per day of butter

Study design

Allocation

Intervention model

SINGLE_GROUP

Primary purpose

BASIC_SCIENCE

Masking

NONE

Eligibility

Sex/Gender

MALE

Age

18 Years to 55 Years

Healthy volunteers

Yes

Inclusion criteria

* 18 to 55 years old * BMI 18 to 30 kg/m² * Stable physical activity * Safety subject during medical consultation

Exclusion criteria

* Medical or surgical history which may affect energy expenditure (renal -cardiovascular -hepatic- endocrine-inflammatory diseases) * Drug use that could affect energy expenditure (steroids, nicotine substitutes, thyroid hormones) * Eating disorder * Intensive sportive activity * Subjects who Smoke * Claustrophobic subjects

Design outcomes

Primary

Measure	Time frame
Post prandial partitioning of exogenous lipids	Before and after overfeeding

Secondary

Measure	Time frame
Genes expression in adipose and muscle tissues	Before and after overfeeding

Countries

France

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026