TRENDY Follow-up: Study on Endothelial Function in Subjects With Type 2 Diabetes Mellitus

Prospective Study on Endothelial Function in Subjects With Type 2 Diabetes Mellitus

Status

Completed

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT00905528

Enrollment

Registered

2009-05-20

Start date

2002-01-31

Completion date

2004-12-31

Last updated

2015-03-25

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Type 2 Diabetes Mellitus

Keywords

type 2 diabetes mellitus, endothelial function, renal hemodynamics

Brief summary

Basal nitric oxide (NO) activity plays a pivotal role in the regulation of glomerular hemodynamics, and in animal experiments its alteration has been associated with morphological changes characteristic of diabetic nephropathy. The investigators aimed to assess in a prospective study: 1. basal NO activity of renal vasculature and 2. renal hemodynamics to examine whether impairment of basal NO activity of the renal vasculature is related to development and progression of diabetic nephropathy and other cardiovascular endpoints.

Interventions

DRUGTelmisartan 80 mg/d

DRUGRamipril 10 mg/d

Study design

Observational model

COHORT

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

30 Years to 80 Years

Healthy volunteers

Inclusion criteria

* Type 2 Diabetes mellitus

Exclusion criteria

* Macroalbuminuria * Symptomatic cardiovascular disease

Design outcomes

Primary

Measure	Time frame
Change in eGFR after 1 year	—

Countries

Germany

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026