Coronary Artery Disease
Conditions
Brief summary
The purpose of this research is to determine the relationship between proteins and enzymes in the blood and how they work with platelets to form blood clots in patients with coronary artery disease. The investigators hypothesize that the relationship between these factors could potentially be useful in identifying patients at higher risk for heart attacks.
Interventions
OTHERBlood draws
Observational: blood draws only
Sponsors
Royal College of Surgeons, Ireland
University College Cork
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* Admission to hospital with suspected index event of Non-ST-Elevation Myocardial Infarction (NSTEMI), Unstable Angina (UA) or Stable Angina (SA) * Planned percutaneous coronary intervention during admission
Exclusion criteria
* Recent history (\< 6 months) of an acute coronary syndrome (other than current admission) or stroke * Recent history (\< 6 months) of major surgery, trauma or thromboembolic event * Percutaneous coronary or peripheral intervention or any stent placement performed within the past 6 months * Current evidence of infection
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| relationships between ADAMTS-13 activity, von Willebrand factor antigen and platelet-monocyte aggregates levels | change from baseline to after percutaneous coronary intervention | Assess the relationships between ADAMTS-13 activity, von Willebrand factor antigen and platelet-monocyte aggregates levels in subjects with coronary artery disease prior to and after undergoing PCI in this exploratory study |
Countries
Ireland
Outcome results
None listed