Breast Cancer
Conditions
Keywords
microarray, gene expression profiling, MammaPrint, breast cancer
Brief summary
By using gene-expression profiling, Van't Veer and colleagues developed a 70-gene prognosis profile, MammaPrint, to identify breast cancer patients who are at low risk of developing distant metastases and therefore might safely be spared chemotherapy. The aim of this study is to evaluate the prognostic value of the 70-gene Mammaprint profile in Japanese women with node-negative breast cancer.
Detailed description
Frozen tumor samples from 140 node-negative, breast cancer patients aged between 29 and 70 years at diagnosis are hybridized on MammaPrint array. Patients were treated with breast conserving therapy or mastectomy with axillary lymph node dissection between December 1998 and August 2001 at Osaka Medical Center for Cancer and Cardiovascular Diseases. Samples are evaluated by gene expression profiling for the 70-gene MammaPrint profile and classified as genomic high risk or genomic low risk.
Interventions
None listed
Sponsors
Osaka General Medical Center
Agendia
Study design
Observational model
COHORT
Time perspective
RETROSPECTIVE
Eligibility
Sex/Gender
FEMALE
Age
29 Years to 70 Years
Healthy volunteers
No
Inclusion criteria
* Breast cancer patients * Node-negative * Treated with breast conserving therapy or mastectomy with axillary lymph node dissection at Osaka Medical Center for Cancer and Cardiovascular Diseases
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The probability of recurrence free survival (PRFS) | 5 years |
Countries
Japan
Outcome results
None listed