Painful Bladder Syndrome
Conditions
Keywords
Painful Bladder Syndrome, Urinary Bladder
Brief summary
The purpose of this study is to determine if clinically relevant subsets exist in patients meeting the diagnosis of Painful Bladder Syndrome (PBS). Subsets suggest differential responses to treatments and if verified, this will be important for the stratification of patients in clinical studies related to PBS.
Detailed description
Patients with the diagnosis of painful bladder syndrome (PBS) constitute two or more phenotypes that are distinguished by differential neurophysiological processing of sensory information. Further, these differing phenotypes can be predicted by the presence or absence of the co-morbidity fibromyalgia.
Interventions
OTHERPhysical examination
Physical examination and multiple questionnaires will be administered
Sponsors
Washington University Early Recognition Center
University of Alabama at Birmingham
Study design
Observational model
CASE_CONTROL
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
19 Years to 75 Years
Healthy volunteers
Yes
Inclusion criteria
* NIDDK criteria for Painful Bladder Syndrome * Age 19 years or older * Must be able to read and speak English since testing materials are validated in English
Exclusion criteria
* PBS subjects must be independent of co-existing pain disorders or use of medications * Uncontrolled hypertension or significant cardiopulmonary disease * No chronic daily pain * Older than 75 years of age
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| This study proposes to examine the sensations that are produced by warming the skin, poking the skin, pressure on muscles and by applying a blood pressure cuff. | One and half to two hours. |
Countries
United States
Outcome results
None listed