Predictors of Cord Blood Immunoglobin E (IgE) Levels

Status

UNKNOWN

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT00902096

Enrollment

800

Registered

2009-05-14

Start date

2009-04-30

Completion date

Unknown

Last updated

2009-05-14

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Atopy

Keywords

cord blood, IgE, prenatal, predictor

Brief summary

Background: Increased total serum IgE levels are a common characteristic of atopic diseases. Increased cord blood IgE levels, in conjunction with a family history of atopy, are associated with the development of allergic diseases in children. However, little is known about predictors of cord blood IgE levels. Objective: The aim of our study was to identify predictors of cord blood IgE levels in an ongoing large birth cohort of infants with or without a family history of atopy. Methods: Blood sampling of mothers was performed just before the delivery of newborns. Cord blood was also collected when the child was born. Maternal and cord blood was measured for IgE levels and cytokines. Questionnaires were administered after birth of the infant.

Interventions

None listed

Study design

Observational model

COHORT

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

ALL

Healthy volunteers

Yes

Inclusion criteria

* Mothers in pregnancy 18 years of age or older, AND * Mothers able to speak Chinese.

Exclusion criteria

* Infant delivered at less than 36 weeks' gestation, * Infant with Apgar score in 5 minutes after birth \< 7, * Infant with a major congenital anomaly, OR * Infant admitted to an intensive care unit.

Design outcomes

Primary

Measure	Time frame
cord blood IgE	at birth

Secondary

Measure	Time frame
Cord blood cytokines or other mediators	at birth

Countries

Taiwan

Contacts

Primary ContactChien-Han Chen, MD

chinsword@yahoo.com.tw886-3-3179599

Outcome results