Desmopressin for Bleeding Related to Low Body Temperature

Effect of Desmopressin on Platelet Dysfunction Associated With Mild Hypothermia in Healthy Volunteers

Status

UNKNOWN

Phases

Phase 4

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT00902057

Enrollment

Registered

2009-05-14

Start date

2009-06-30

Completion date

2011-06-30

Last updated

2009-05-14

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Hypothermia Induced Impairment of Primary Haemostasis

Brief summary

To study, with a prospective randomised controlled design, whether the subcutaneous administration of the haemostatic drug desmopressin, may improve the impairment of primary haemostasis due to mildly decreased temperature.

Interventions

DRUGdesmopressin

single desmopressin subcutaneous injection, 1.5mcg

DRUGplacebo

saline subcutaneous

Study design

Allocation

RANDOMIZED

Intervention model

PARALLEL

Primary purpose

TREATMENT

Masking

TRIPLE (Subject, Investigator, Outcomes Assessor)

Eligibility

Sex/Gender

ALL

Age

18 Years to 50 Years

Healthy volunteers

Yes

Inclusion criteria

1\. Healthy volunteers

Exclusion criteria

1. Any known platelet or coagulation disorder. 2. Pregnant or lactating women. 3. Known chronic liver or renal disease. 4. Coronary artery, carotid artery or peripheral artery disease 5. Recent history of taking antiplatelet drugs, anticoagulants or herbal preparations. 6. Smoker or alcohol user 7. Mentally incapable of providing informed consent 8. Students or junior staff members who had direct working relationship with the PI

Design outcomes

Primary

Measure	Time frame
closure time on PFA-100	3 hours

Countries

China

Contacts

Primary ContactKwok F.J. Ng, MBChB, MD, MBA, FANZCA, FHKAM

jkfng@hku.hk(852) 28553303

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026