Postmenopause, Premenopause
Conditions
Keywords
n-3 PUFAs, menopause, adipose tissue, estrogens, Incorporation of fishoil in pre- and postmenopausal women, Marine n-3 PUFAs influence on female hormones in blood
Brief summary
The study is a randomised placebo controlled double-blinded clinical trial where a group of healthy pre- and postmenopausal women is randomised to the intake of fish oil capsules or placebo oil capsules for 12 weeks. Anthropometric measurements(weight, height,blood pressure) blood samples and adipose tissue biopsies will be taken in order to illustrate the effect of marine n-3 PUFAs (fish oil) on the concentration of circulating female hormones and to investigate what impact menopause might have on the ability to incorporate marine n-3 PUFAs into tissues.
Interventions
DIETARY_SUPPLEMENTmarine n-3 polyunsaturated fatty acids
Four capsules daily containing 2.2 g marine n-3 polyunsaturated fatty acids in total
DIETARY_SUPPLEMENTthistle oil
four capsules a day
DIETARY_SUPPLEMENTThistle oil
Four capsules daily
Sponsors
Aalborg University Hospital
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
BASIC_SCIENCE
Masking
QUADRUPLE (Subject, Caregiver, Investigator, Outcomes Assessor)
Eligibility
Sex/Gender
FEMALE
Age
18 Years to 70 Years
Healthy volunteers
Yes
Inclusion criteria
* age 18-70 years old * healthy or well-treated chronic disease
Exclusion criteria
* hormone treatment * foreseen compliance problem * fish oil consumers
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Content of marine n-PUFAs as percent of total content of fatty acids in adipose tissue and in platelets before and after intervention | — |
Secondary
| Measure | Time frame |
|---|---|
| Measurement of oestrogen concentrations in blood before and after intervention | — |
Countries
Denmark
Outcome results
None listed