Cardiac Arrest
Conditions
Keywords
therapeutic hypothermia after cardiac arrest
Brief summary
Recently, early defibrillation and cardiopulmonary resuscitation (CPR) for sudden onset of cardiac arrest are advancing, however, survival rate is still very low in the world. Furthermore, post-cardiac arrest brain injury is a common cause of morbidity and mortality after successful resuscitation which is urgent issue to be solved. Therapeutic hypothermia is part of a standardized treatment strategy for comatose survivors of cardiac arrest in the metabolic phase usually about 15 minutes after cardiac arrest. However, the evidences of the efficacy of therapeutic hypothermia are still few. The optimal candidates, temperature, the timing of initiation, the therapeutic windows and the rate for rewarming have not been defined clinically and should be established. The purpose of this research is the improvement in the outcomes for patients with coma after resuscitation from out-of-hospital cardiac arrest using therapeutic hypothermia established from the analysis of multicenter registry data.
Interventions
None listed
Sponsors
National Cerebral and Cardiovascular Center, Japan
Study design
Observational model
COHORT
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* Adult patients who remained unconscious after resuscitation from out-of-hospital or inhospital cardiac arrest * Presented the stable hemodynamics with drug treatments or mechanical supporting system including IABP or PCPS
Exclusion criteria
* Patients with: * pregnancy * acute aortic dissection * pulmonary thromboembolism * drug poisoning * poor daily activity
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Survival and functional outcome (CPC: Cerebral Performance Categories) | after 3 months |
Secondary
| Measure | Time frame |
|---|---|
| Survival and/or functional outcome | after 24 hours |
| Survival or functional outcome | after three months |
Countries
Japan
Outcome results
None listed