Effect of Systemic Ropivacaine on Hyperalgesia, Flare Reaction and Peripheral Nerve Excitability

Effect of Systemic Ropivacaine on Hyperalgesia, Flare Reaction and Peripheral

Status

Completed

Phases

Phase 4

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT00900913

Enrollment

Registered

2009-05-13

Start date

2010-01-31

Completion date

2011-07-31

Last updated

2011-08-08

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Healthy Volunteers

Brief summary

The purpose of this study is to compare the effect of intravenous ropivacaine and lidocaine on the receptive field of primary sensory afferents and their influence on the vascular bed. \*Trial with medicinal product

Interventions

DRUGropivacaine (Naropin)

intravenous infusion 1 mg/kg bw

Study design

Allocation

RANDOMIZED

Intervention model

CROSSOVER

Primary purpose

TREATMENT

Masking

TRIPLE (Subject, Investigator, Outcomes Assessor)

Eligibility

Sex/Gender

MALE

Age

18 Years to 65 Years

Healthy volunteers

Inclusion criteria

1. Male 2. Age: 18 - 65 years 3. Weight: 50-100kg 4. Height: 155-195cm 5. Signed and dated informed consent 6. Sufficient command of German language

Exclusion criteria

1. Contraindications to the class of drugs under study 2. Vulnerable subjects (intellectually or mental impaired) 3. Known hypersensitivity to class of drugs or the investigational product 4. Drug abuse 5. Known peripheral neuropathies 6. Diabetes mellitus 7. Chronic alcohol consumption 8. Congestive heart disease 9. Participants of other studies during study period 10. Smoker

Design outcomes

Primary

Measure	Time frame
Aera of flare reaction (cm2), area of primary and secondary hyperalgesia (cm2)	1 year

Countries

Switzerland

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026