Esophageal Cancer, Head and Neck Cancer, Lung Cancer, Precancerous Condition
Conditions
Keywords
non-small cell lung cancer, small cell lung cancer, squamous lung dysplasia, hypopharyngeal cancer, laryngeal cancer, lip and oral cavity cancer, metastatic squamous neck cancer with occult primary, nasopharyngeal cancer, oropharyngeal cancer, paranasal sinus and nasal cavity cancer, salivary gland cancer, esophageal cancer, pulmonary carcinoid tumor, tongue cancer
Brief summary
RATIONALE: Studying samples of sputum and tissue in the laboratory from patients with dysplasia or cancer may help doctors identify and learn more about biomarkers related to cancer. It may also help the study of cancer in the future. PURPOSE: This laboratory study is looking at biomarkers in patients with respiratory tract dysplasia or lung cancer, head and neck cancer, or aerodigestive tract cancer.
Detailed description
OBJECTIVES: Primary * Determine intermediate biomarkers of premalignant respiratory epithelial lesions, such as genetic mutations or altered growth factor expression, in patients with dysplasia of the respiratory epithelium or lung cancer, head and neck cancer, or aerodigestive tract cancer. Secondary * Establish a tissue repository of normal and dysplastic respiratory epithelium from endobronchial forceps and brush biopsy tissue from these patients and from normal volunteers. OUTLINE: Patients are stratified according to presence of extensive and severe dysplasia of the respiratory epithelium (yes vs no). Participants undergo sputum cytology, white-light (with or without fluorescence) bronchoscopy, and endobronchial biopsies. Participants also undergo endobronchial brushings and bronchial secretion collection and possibly bronchoalveolar lavage. Collected samples are processed by hematoxylin, eosin, and immunohistochemical staining and analyzed for specific biomarkers. Unused samples are stored in the tissue bank. PROJECTED ACCRUAL: A total of 330 participants will be accrued for this study.
Interventions
OTHERimmunohistochemistry staining method
Laboratory test
OTHERlaboratory biomarker analysis
Laboratory Test
OTHERsputum cytology
Laboratory Test
PROCEDUREbiopsy
Laboratory Test
Sponsors
National Cancer Institute (NCI)
University of Colorado, Denver
Study design
Observational model
OTHER
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
21 Years to 90 Years
Healthy volunteers
No
Inclusion criteria
* Diagnosis of extensive and severe dysplasia of the respiratory epithelium * Those without dysplasia of the respiratory epithelium * Recruited from the SPORE Tissue Procurement Screening Project or by private or academic physicians (for patients with moderate or severe dysplasia) * Survived 1 or more aerodigestive system carcinoma for ≥ 1 year * Completely resected stage I non-small cell cancer * Undergoing any of the following procedures: * Routine panendoscopy for patients with head and neck cancer * Resection of a bronchogenic carcinoma * Bronchoscopy for diagnosis or staging of suspected lung cancer * Subsequent bronchoscopy for surveillance or monitoring of response to endobronchial treatment in patients with prior high-grade dysplasia or worse * No asthma * No lung disease * No respiratory illness within the past 2 weeks Patients suspected of or at risk for neoplastic lung disease who are undergoing a bronchoscopy in which differential diagnostic considerations may include multiple other etiologies such as infection and other processes. * Patients without dysplasia will be: patients undergoing clinically indicated bronchoscopy for conditions other than suspected lung cancer. PATIENT CHARACTERISTICS: * No clinically apparent bleeding diathesis * No known bleeding disorder * No anginal * No clinically active coronary artery disease * No multifocal premature ventricular contractions * No poorly controlled congestive heart failure * No myocardial infarction within the past 6 weeks * No cardiac dysrhythmia that is potentially life threatening * Well-controlled atrial fibrillation or rare (\< 2/min) premature ventricular contractions allowed * No ventricular tachycardia or supraventricular tachycardia with a rapid ventricular response * No other serious medical condition that would preclude a patient from undergoing a bronchoscopy * No acute bronchitis or pneumonia within the past 8 weeks except when clinically proven as a possible result of lung cancer * No hypoxemia (i.e., \< 90% saturation with supplemental oxygen) before bronchoscopy PRIOR CONCURRENT THERAPY: * See Disease Characteristics
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Genetic mutations or altered growth factor expression | After study has completed |
Secondary
| Measure | Time frame |
|---|---|
| Establishment of a tissue repository of normal and dysplastic respiratory epithelium | After study has closed |
Countries
United States
Contacts
Primary ContactBrandi Kubala
Outcome results
None listed