Nutrition-Related Biomarkers in Predicting Breast Cancer Risk in Women

Nutrition Modulated Metabolism as a Disease Risk Factor

Status

UNKNOWN

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT00900367

Enrollment

1500

Registered

2009-05-12

Start date

2005-07-31

Completion date

2025-12-31

Last updated

2019-08-13

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Breast Cancer

Keywords

breast cancer

Brief summary

RATIONALE: Studying samples of blood from patients with cancer in the laboratory may help doctors learn more about nutrition-related changes that identify biomarkers related to cancer. It may also help doctors predict a woman's risk of developing breast cancer. PURPOSE: This laboratory study is looking at nutrition-related biomarkers in predicting breast cancer risk in women.

Detailed description

OBJECTIVES: * To complete characterization of metabolic serotypes based on the metabolome, and to adapt these profiles for human epidemiological studies. * To determine the extent to which metabolic profiles that are reflective of or independent of long-term caloric intake predict breast cancer risk in nested case-control studies. * To identify critical serum metabolites. OUTLINE: Laboratory studies, including metabolome profiling by high performance liquid chromatography; and small molecule identification by mass spectroscopy, are performed on previously collected blood samples.

Interventions

OTHERhigh performance liquid chromatography

OTHERlaboratory biomarker analysis

PROCEDUREspectroscopy

Study design

Observational model

COHORT

Time perspective

OTHER

Eligibility

Sex/Gender

FEMALE

Age

No minimum to 120 Years

Healthy volunteers

Yes

Inclusion criteria

DISEASE CHARACTERISTICS: * Meets 1 of the following criteria: * Confirmed breast cancer that was diagnosed at least 2 years after blood sample collection (case) * No prior diagnosis of cancer * Healthy participant (control) * Enrolled in the Nurses' Health Study * Banked blood samples available * Hormone receptor status not specified PATIENT CHARACTERISTICS: * Menopausal status not specified PRIOR CONCURRENT THERAPY: * Not specified

Design outcomes

Primary

Measure	Time frame
Generation of metabolome profiles that reflect nutritional status	ongoing
Utility of rat metabolome profiles for human epidemiological studies	ongoing
Utility of metabolome profiles in predicting relative risk of developing breast cancer	ongoing
Identification of critical serum metabolites	ongoing

Countries

United States

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026