Studying Tumor Tissue Samples From Patients With Soft Tissue Sarcoma

LABORATORY STUDIES OF SOFT TISSUE SARCOMAS

Status

Completed

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT00900341

Enrollment

Registered

2009-05-12

Start date

2005-08-31

Completion date

2013-06-30

Last updated

2014-03-21

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Sarcoma

Keywords

adult soft tissue sarcoma, childhood soft tissue sarcoma

Brief summary

RATIONALE: Studying samples of tumor tissue from patients with cancer in the laboratory may help doctors learn more about changes that occur in DNA and identify biomarkers related to cancer. PURPOSE: This research study is looking at tumor tissue samples from patients with soft tissue sarcoma.

Detailed description

OBJECTIVES: * To develop a pilot program for the collection, archiving, and experimental analyses of soft tissue sarcomas (STS). * To obtain STS tumors from cancer patients undergoing tumor removal or core needle biopsies. * To evaluate cellular and molecular factors involved in STS oncogenesis by studying samples derived from human tumor specimens. * To develop an accompanying bioinformatics database of the demographics of STS patients from which tumor specimens are derived for experimental study. OUTLINE: Tumor tissue samples are analyzed for gene and protein expression by cDNA microarray analysis, RT-PCR, immunohistochemistry, in vitro transformation assays, RNA interference, and Western blot or immunoprecipitation.

Interventions

GENETICDNA analysis

GENETICgene expression analysis

GENETICprotein expression analysis

GENETICreverse transcriptase-polymerase chain reaction

GENETICwestern blotting

OTHERimmunohistochemistry staining method

OTHERlaboratory biomarker analysis

Study design

Observational model

CASE_ONLY

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

ALL

Healthy volunteers

Inclusion criteria

DISEASE CHARACTERISTICS: * Meets one of the following criteria: * Patients with soft tissue sarcoma (STS) undergoing evaluation, treatment, and/or follow-up at the Arizona Cancer Center or University Medical Center * Patients undergoing surgical treatment for STS removal or core needle biopsy for medically indicated diagnostic or therapeutic purposes PATIENT CHARACTERISTICS: * Not specified PRIOR CONCURRENT THERAPY: * Not specified

Design outcomes

Primary

Measure	Time frame
Identification of molecular targets that would improve the diagnosis, prognosis, and/or treatment of STS	3 months

Countries

United States

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026