Tissue Sample Collection From Patients With Fanconi Anemia

Fanconi Anemia Cancer Cell Repository

Status

Completed

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT00899522

Enrollment

Registered

2009-05-12

Start date

2005-08-31

Completion date

2013-05-31

Last updated

2017-12-04

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Fanconi Anemia, Unspecified Adult Solid Tumor, Protocol Specific, Unspecified Childhood Solid Tumor, Protocol Specific

Keywords

Fanconi anemia, unspecified adult solid tumor, protocol specific, unspecified childhood solid tumor, protocol specific

Brief summary

RATIONALE: Collecting and storing samples of tumor tissue from patients with Fanconi anemia to test in the laboratory may help the study of cancer in the future. PURPOSE: This laboratory study is collecting and storing tumor tissue samples from patients with Fanconi anemia.

Detailed description

OBJECTIVES: * Acquire rare solid tumor samples from patients with Fanconi anemia in order to create a Fanconi Anemia Cell Repository at the Oregon Health and Science University Cancer Institute. * Study repository tissue using a variety of molecular methods, including gene microarrays. * Develop cancer cell lines that are publicly available from tissue archived from patients with Fanconi anemia. OUTLINE: Tumor biopsies are collected from patients with Fanconi anemia and archived for future molecular studies, cell line generation, and general usage by the research community at large. Medical information about the patient's cancer is also archived. PROJECTED ACCRUAL: Not specified.

Interventions

OTHERbiologic sample preservation procedure

Once the pathologist has taken the material needed to establish diagnosis of cancer, the anonymized snap-frozen and fresh samples will be either shipped to our laboratory for analysis or will be picked up by a member of the principal investigator's lab team. Samples will be stored indefinitely.

PROCEDUREbiopsy

Once the pathologist has taken the material needed to establish diagnosis of cancer, 1-10 grams of the remaining tissue should be placed in phosphate buffered saline and shipped to the Bagby Lab.

Study design

Observational model

CASE_CONTROL

Time perspective

RETROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

1 Years to 55 Years

Healthy volunteers

Inclusion criteria

DISEASE CHARACTERISTICS: * Confirmed Fanconi anemia * Confirmed malignant solid tumor * Biopsy of tumor tissue available PATIENT CHARACTERISTICS: * Not specified PRIOR CONCURRENT THERAPY: * Not specified

Design outcomes

Primary

Measure	Time frame
Creation of a Fanconi Anemia Cell Repository using rare solid tumor samples from patients with Fanconi anemia	Duration of the study
Study tissue samples by molecular methods, including gene microarrays	Duration of the study
Development of cancer cell lines from tissue archived from patients with Fanconi anemia	Duration of the study

Countries

United States

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026