Protein Expression in Tumor Tissue Samples From Patients With Cancer of the Oropharynx

Protein Expression Profiles in Oropharyngeal Squamous Cell Carcinoma

Status

Completed

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT00899340

Enrollment

Registered

2009-05-12

Start date

2006-05-31

Completion date

2008-03-31

Last updated

2013-04-02

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Head and Neck Cancer

Keywords

recurrent squamous cell carcinoma of the oropharynx, stage I squamous cell carcinoma of the oropharynx, stage II squamous cell carcinoma of the oropharynx, stage III squamous cell carcinoma of the oropharynx, stage IV squamous cell carcinoma of the oropharynx

Brief summary

RATIONALE: Studying the proteins expressed in samples of tumor tissue from patients with cancer may help doctors identify and learn more about biomarkers related to cancer. It may also help doctors plan better treatment for patients with cancer of the oropharynx. PURPOSE: This laboratory study is looking at protein expression in tumor tissue samples from patients with cancer of the oropharynx.

Detailed description

OBJECTIVES: * To investigate if some of the differences in gene expression are also reflected at the protein level. * To determine whether differences in gene expression that are also reflected at the protein level can be used to develop markers for early detection and disease surveillance. * To identify targets for therapy. OUTLINE: Archived tumor tissue samples are analyzed for expression of standard immunohistological markers (e.g., p16, p53, and Ki-67) as well as expression of genes identified in a previous gene expression study. Protein expression data are tested for clinical and demographic correlates and compared with gene expression data.

Interventions

GENETICgene expression analysis

profiles of HPV(+) and (-) HNSCCs

GENETICmicroarray analysis

microarray analysis

GENETICprotein expression analysis

protein expression analysis

OTHERimmunohistochemistry staining method

immunohistochemistry staining method

OTHERlaboratory biomarker analysis

laboratory biomarker analysis

Study design

Observational model

CASE_ONLY

Time perspective

RETROSPECTIVE

Eligibility

Sex/Gender

ALL

Healthy volunteers

Inclusion criteria

* Diagnosis of squamous cell carcinoma of the oropharynx * Tumor tissue samples available from Vanderbilt Head and Neck Tumor Repository and Vanderbilt Pathology archives

Exclusion criteria

* Not specified PRIOR CONCURRENT THERAPY: * Not specified

Design outcomes

Primary

Measure	Time frame
Development of biomarkers for early detection or recurrence surveillance	after 7 months of tissue collection
Identification of therapeutic targets and individualization of treatment based on the biology of squamous cell carcinoma of the oropharynx	after 7months of tissue collection

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026