Collecting and Storing Samples of Blood and Tumor Tissue From Patients With Osteosarcoma

A Children?s Oncology Group Protocol for Collecting and Banking Osteosarcoma Specimens

Status

Completed

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT00899275

Enrollment

957

Registered

2009-05-12

Start date

2008-02-04

Completion date

2023-09-30

Last updated

2023-10-03

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Osteosarcoma

Brief summary

The purpose of this study is to collect and store samples of blood and tumor tissue from patients with osteosarcoma. Collecting and storing samples of tumor tissue and blood from patients to test in the laboratory may help the study of cancer in the future.

Detailed description

OBJECTIVES: I. To collect biological specimens from patients with osteosarcoma at Children?s Oncology Group (COG) institutions. II. To provide a repository for long-term storage of osteosarcoma-related biological materials. III. To make these specimens available to qualified researchers to understand the biology of osteosarcoma and correlate these results with the patients' clinical data. OUTLINE: After the initial submission of blood samples, patients may undergo open or closed biopsy in order to obtain fresh and frozen tissue samples as well as paraffin embedded material. Patients who are enrolled at the time of initial diagnosis but then have a definitive surgery or develop recurrent disease may submit additional samples (paraffin block, frozen and fresh tumor tissue, or slides together with blood samples). Autopsy tumor samples may also be submitted.

Interventions

OTHERCytology Specimen Collection Procedure

Correlative studies

Study design

Observational model

OTHER

Time perspective

RETROSPECTIVE

Eligibility

Sex/Gender

ALL

Healthy volunteers

Inclusion criteria

* All osteosarcoma patients seen at COG institutions are eligible, including the following: * Newly diagnosed patients * Patients with recurrent disease who were not enrolled at the time of diagnosis * The following specimens from the initial biopsy (and/or definitive surgery if an up-front resection is performed) are required: * Paraffin embedded block OR 30 unstained slides * Pretreatment blood consisting of 5 mL serum, 10 mL plasma, and 10 mL heparinized whole blood * Fresh and frozen tumor specimens * Patients are not required to enter a therapeutic study to enroll on this study

Design outcomes

Primary

Measure	Time frame
Collection of biological specimens from patients with osteosarcoma	Baseline

Countries

Australia, Canada, New Zealand, Puerto Rico, United States

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026