Lymphoma
Conditions
Keywords
Waldenström macroglobulinemia
Brief summary
RATIONALE: Collecting and storing stem cells to study in the laboratory may help doctors learn more about collecting stem cells from patients who have undergone treatment for Waldenstrom's macroglobulinemia. PURPOSE: This laboratory study is collecting stem cells from patients with Waldenstrom's macroglobulinemia.
Detailed description
OBJECTIVES: * Harvest and store adequate CD34+ stem cells from patients with Waldenstrom's macroglobulinemia (WM) for potential future use in transplantation strategies. * Evaluate the ability to harvest stem cells after therapy for WM (e.g., fludarabine-based chemotherapy) by evaluating the number of days to adequate harvest. * Collect aliquots of stem cells for future research analysis as part of a WM database project. OUTLINE: Patients undergo collection of autologous stem cells beginning on day 4 or 5 and continuing until an adequate number of stem cells are collected. Cells are then cryopreserved. PROJECTED ACCRUAL: A total of 40 patients will be accrued for this study.
Interventions
PROCEDUREleukapheresis
Sponsors
National Cancer Institute (NCI)
Herbert Irving Comprehensive Cancer Center
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
DISEASE CHARACTERISTICS: * Diagnosis of Waldenstrom's macroglobulinemia (WM) * Less than 30% lymphoplasmacytoid cells in bone marrow by histopathology * Received prior chemotherapy for WM PATIENT CHARACTERISTICS: * ECOG performance status 0-1 * WBC \> 2,000/mm³ * Platelet count \> 50,000/mm³ * LVEF ≥ 50% * No organ dysfunction that would preclude future transplantation PRIOR CONCURRENT THERAPY: * See Disease Characteristics
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Number of days to adequate stem cell harvest | — |
Countries
United States
Outcome results
None listed