Unspecified Adult Solid Tumor, Protocol Specific, Unspecified Childhood Solid Tumor, Protocol Specific
Conditions
Keywords
unspecified adult solid tumor, protocol specific, unspecified childhood solid tumor, protocol specific
Brief summary
RATIONALE: Studying samples of blood from patients with cancer in the laboratory may help doctors learn more about the effect of bevacizumab and VEGF on platelet clustering. PURPOSE: This research study is looking at the effect of bevacizumab and VEGF on platelet clustering in patients with cancer who are receiving bevacizumab.
Detailed description
OBJECTIVES: * To determine the influence of bevacizumab on platelet aggregation in patients receiving bevacizumab for cancer. * To determine the influence of VEGF on platelet aggregation. * To determine the influence of VEGF or bevacizumab on cyclooxygenesis. * To determine if the sequence of medication plays a role in platelet aggregation. OUTLINE: Blood samples are collected before and after bevacizumab infusion. Samples are analyzed for measurements of platelet aggregation, coagulation parameters, and endothelial activation (e.g., fibrin fragment F1 and 2, thrombin and antithrombin complex, soluble P-selectin, Von Willebrand factor and factor VIII, tissue factor, and endothelin 1).
Interventions
Sponsors
Kantonsspital Graubuenden
Eligibility
Sex/Gender
ALL
Healthy volunteers
No
Inclusion criteria
DISEASE CHARACTERISTICS: * Receiving bevacizumab for cancer PATIENT CHARACTERISTICS: * Not specified PRIOR CONCURRENT THERAPY: * See Disease Characteristics
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Influence of bevacizumab on platelet aggregation | — |
| Influence of VEGF on platelet aggregation | — |
| Influence of VEGF or bevacizumab on cyclooxygenesis | — |
| Correlation between medication sequence and platelet aggregation | — |
Countries
Switzerland
Outcome results
None listed