Pancreatic Cancer
Conditions
Keywords
recurrent pancreatic cancer, stage IV pancreatic cancer
Brief summary
RATIONALE: Studying samples of tumor tissue from patients with cancer in the laboratory may help doctors learn more about changes that may occur in DNA and identify biomarkers related to cancer. PURPOSE: This laboratory study uses gene expression profiling to compare primary tumor cells with metastatic tumor cells in patients with metastatic pancreatic cancer.
Detailed description
OBJECTIVES: * Compare the gene expression profiles of pancreatic cancer cells from the primary and metastatic sites in patients with metastatic pancreatic cancer. * Characterize the function of the differentially upregulated and downregulated genes identified by comparing the gene expression profiles of primary and metastatic cells in these patients. OUTLINE: Fresh biopsy samples are collected for gene expression profiling and other biomarker/laboratory analyses. PROJECTED ACCRUAL: A total of 10 patients will be accrued for this study.
Interventions
GENETICmicroarray analysis
OTHERlaboratory biomarker analysis
Sponsors
National Cancer Institute (NCI)
Barbara Ann Karmanos Cancer Institute
Study design
Observational model
CASE_ONLY
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Healthy volunteers
No
Inclusion criteria
DISEASE CHARACTERISTICS: * Diagnosis of pancreatic adenocarcinoma of exocrine origin * Metastatic disease * Fresh biopsy material available from primary site of disease and a metastatic focus, including liver, peritoneum, or lymph node PATIENT CHARACTERISTICS: * Not specified PRIOR CONCURRENT THERAPY: * No prior chemotherapy or radiotherapy for pancreatic cancer
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Gene expression profiles | at time of biopsy |
Countries
United States
Outcome results
None listed