Breast Cancer
Conditions
Keywords
breast cancer
Brief summary
RATIONALE: Changing the genes in laboratory mice to create a living model of human breast cancer may help doctors learn more about breast cancer. PURPOSE: This research study is developing mouse models of breast cancer using tissue samples that were previously collected from women with breast cancer.
Detailed description
OBJECTIVES: * To develop new in vivo models of human breast cancer. * To correlate response in this model to actual treatment outcome in patients, if the in vivo model is proven feasible. OUTLINE: Previously collected breast tumor fragments are implanted into the renal capsule site of SCID mouse hosts (mouse with severe combined immune deficiency) to establish metastatic spread patterns, and both histologic and molecular tumor characteristics. Patients' medical charts are reviewed to obtain relevant information, including general demographics, smoking and alcohol use, as well as outcome data such as survival and response to treatment.
Interventions
OTHERlaboratory biomarker analysis
Tissue samples will either be collected at the time of medically indicated surgical procedures or through research core biopsies. A sample of urine will also be obtained. Blood will be collected via venipuncture and lymphocytes (mononuclear cells) separated and processed as a source of normal DNA and normal cells.
OTHERmedical chart review
patient chart review will occur in conjunction with patient data collection for final analyses.
Sponsors
National Cancer Institute (NCI)
Vanderbilt-Ingram Cancer Center
Study design
Observational model
CASE_ONLY
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
FEMALE
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
DISEASE CHARACTERISTICS: * Diagnosis of breast cancer * Any stage of disease * Primary or metastatic disease * Human breast tumor tissues available after the diagnoses have been made * Enrolled on the ongoing Breast Tissue Repository trial VU-VICC-BRE-03103 * Have consented to the use of their tissues for research purpose * Hormone receptor status not specified PATIENT CHARACTERISTICS: * Menopausal status not specified PRIOR CONCURRENT THERAPY: * Not specified
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Development of new in vivo models of human breast cancer | 1 year |
| Correlation of response in this model to actual treatment outcome in patients, if the in vivo model proven feasible | 5 years |
Countries
United States
Outcome results
None listed