Astrocytomas, Oligoastrocytoma, Oligodendrogliomas
Conditions
Brief summary
Although the prognosis of patients with low-grade glioma (LGG) is generally good, recurrence seems unavoidable in some patients because of the infiltrative growth of the tumors. How to treat LGGs is still under controversy. The role of radiation therapy and chemotherapy in the treatment of LGG need to be further investigated. The purpose of this study is the following: 1. to investigate the role of early radiation therapy in MRI-determined total resected LGGs; 2. to compare the efficacy of early radiation therapy and that of initial chemotherapy in the LGGs without total resection.
Interventions
RADIATIONRadiation therapy
DRUGTemozolomide
Sponsors
Sun Yat-sen University
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
18 Years to 60 Years
Healthy volunteers
No
Inclusion criteria
* Histologically confirmed newly diagnosed low-grade gliomas * Karnofsky performance status of 60 or more
Exclusion criteria
* Previous history of radiation therapy or chemotherapy for gliomas * Pregnant or breast feeding * Diagnosis of another malignancy may exclude subject from study * Evidence or history of bleeding diathesis * Evidence or history of hypersensitivity to temozolomide
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Efficacy of early radiation therapy in MRI-determined total resected LGGs: evaluated as 5-year progression-free survival. | 10 years |
| Efficacy of early radiation therapy vs. initial chemotherapy with temozolomide in LGGs without total resection: evaluated as 5-year progression-free survival. | 10 years |
Countries
China
Outcome results
None listed